Proteolysis Targeting Chimeras (PROTAC): Bifunctional molecules designed to induce the degradation of specific proteins by harnessing the ubiquitin-proteasome system. Celastrol and Its Effects on ...

Identifying proteomic signatures of insulin resistance in fasting muscle offers insights for personalized type 2 diabetes ...

Intracellular protein trafficking and secretion of proteins into the extracellular environment are sequential and tightly ...

The heart is a never-stopping engine that relies on a formidable pool of mitochondria to generate energy and propel pumping. Because dying cardiomyocytes cannot be replaced, this high metabolic rate ...

Ethnopharmacological relevance: Celastrol, a bioactive compound from Tripterygium ... with a primary focus on protein domain-specific binding, ubiquitin-like protein ligase binding, and kinase binding ...

Key Laboratory of Pesticide & Chemical Biology of the Ministry of Education, Hubei Key Laboratory of Genetic Regulation and Integrative Biology, School of Life Sciences, Central China Normal ...