Proteolysis Targeting Chimeras (PROTAC): Bifunctional molecules designed to induce the degradation of specific proteins by harnessing the ubiquitin-proteasome system. Celastrol and Its Effects on ...

The ubiquitin proteasome system (UPS) regulates the ubiquitination, and thus degradation and turnover, of many proteins vital to cellular regulation and function. The UPS comprises a sequential series ...

Polyubiquitination targets proteins for recognition and processing by the 26S proteasome, a cylindrical organelle that recognizes ubiquitinated proteins, degrades the proteins, and recycles ubiquitin.

As the maintenance of protein homeostasis is essential to human health, malfunctions of the ubiquitin-proteasome system (UPS) causes various diseases such as cancers, inflammation, and ...

This vital task falls upon specialized enzymes known as ubiquitin ligases, which tag obsolete proteins for degradation, guiding them to the cellular recycling center, the proteasome. Ubiquitin ...

Protein turnover is crucial in maintaining cellular homeostasis and this process is largely controlled by the Ubiquitin Proteasome Pathway (UPP). The pathway consists of an enzymatic cascade that ...

As the maintenance of protein homeostasis is essential to human health, malfunctions of the ubiquitin-proteasome system (UPS) causes various diseases such as cancers, inflammation, and ...

The big biotech firm Celgene will work with San Francisco-based Nurix to develop small molecules that function through the ubiquitin-proteasome system (UPS) to modulate protein homeostatis.

And while cells typically tag proteins destined for proteasomal destruction with the small molecule ubiquitin, the newly reported study found that midnolin-proteasome mechanism bypasses this ...

The protein tagged with ubiquitins is referred to as a polyubiquitin chain and this is bound by the proteasome for degradation. This overall process of protein degradation is termed the ubiquitin ...