Cas9 leaves a blunt end cut, while Cas12 leaves a 5’ overhang, but this would not appear to have a meaningful impact on the types of edits that can be accomplished. One important difference is that ...

When the enzyme encounters a target, such as a cancer-linked gene, it activates and begins shredding nearby DNA on the sensor ...

Using an inexpensive electrode coated with DNA, MIT researchers have designed disposable diagnostics that could be adapted to ...

DETECTR takes advantage of Cas9’s less famous cousin, Cas12. Like Cas9, Cas12 follows a guide RNA towards a target and cuts it up. Be Part of the Future. Sign up to receive top stories about ...

While both Cas9 and Cas12 cut DNA targets, Cas12 can increase the output signal by performing cuts on "collateral" DNA. This can make detection technologies more sensitive and, ...

According to this paper, Cas12 is a more precise gene-modifying instrument than Cas9. “We show that Cas12a binds DNA tightly in two kinetically separable steps,” the article’s authors wrote.

While both Cas9 and Cas12 cut DNA targets, Cas12 can increase the output signal by performing cuts on "collateral" DNA. This can make detection technologies more sensitive and, therefore, more ...

MIT has developed a DNA sensor that can detect HPV and HIV infections through voltage changes. The sensor is durable and ...

Cas9 or Cas12? Picking the Right CRISPR System for Your Research CRISPR technology has revolutionized the life sciences, opening up new possibilities for novel technologies that will help to change ...