Cancer-associated fibroblasts (CAFs) are an important component in solid tumors. They play a decisive role in cancer development and have a significant influence on the success of therapy. The ...

Chemokines, our body's chemical messengers, play a crucial role in regulating the immune response.  They are secreted by ...

Some cancer cells circumvent GOT2 loss through macropinocytosis or by acquiring metabolites from cancer-associated fibroblasts, allowing them to replenish aspartate independently.

A study demonstrates the role of the Galectin-1 protein in the nucleus of the cells surrounding the tumor -- fibroblasts -- contributing to their activation. Activated fibroblasts promote tumor growth ...

Lipid metabolism has emerged as a central player in the progression and therapy resistance of breast cancer, particularly the aggressive subtype known as triple-negative breast cancer (TNBC).

Study Identifies Subtypes of Fibroblasts in Skin Cancer Nov. 19, 2024 — A study provides insights into the diversity of cancer-associated fibroblasts in white and black skin cancer and describes ...

"The stroma is considered a key component in the aggressive nature of pancreatic cancer, as it interacts with tumor cells, protects them, and hinders the action of drugs. Moreover, stromal cells, ...

So, Santi and her colleagues at the Cancer Research UK Scotland Institute, where she previously worked as a postdoctoral researcher, investigated how their function is influenced by surrounding cells.

Our research focuses on the tumor-permissive molecular mechanisms underlying cancer-associated fibroblast function as well as immune suppression, and how these stromal mechanisms affect cell fate and ...