Understanding the pathways modulated by calpain might be instrumental in ... phospho-FoxO3A-Thr 32 and PP2Ac (Upstate Cell Signaling, Lake Placid, NY, USA), Akt detection kit (Cell Signaling ...

In neurons, mitogen-activated protein kinase (MAPK) regulates a variety of signal transduction pathways, including those involved ... the proteasome, or calpain might be the proteolytic culprit.

Calpains are Ca 2+-dependent cysteine proteases (proteolytic enzymes with cysteine in the catalytic site) that modulate cellular function. In humans, 14 independent genes encode members of the ...

"We found an entire signaling pathway in the human host cell that ... of this pathway in both parasitic organisms." Independent of calpain, the researchers also found that host PKC played an ...

The authors therefore suggest that calpain inhibitors improve memory in APP/PS1 mice because they reestablish normal signaling between nerve cells.

The authors therefore suggest that calpain inhibitors improve memory in APP/PS1 mice because they reestablish normal signaling between nerve cells. TITLE: Inhibition of calpains improves memory ...