Calpain expression is altered during tumorigenesis, and the proteolysis of numerous substrates, such as inhibitors of nuclear factor-κB (IκB), focal adhesion proteins (including, focal adhesion ...

Some calpain ... calpains to their substrates, rather than promote autolysis. 16–23 μ-Calpain and m-calpain have diverse functions. 11,32 They catalyze the proteolysis of proteins involved ...

We now provide direct evidence that calpain-mediated proteolysis of a specific substrate, talin, regulates the disassembly of cell-substratum adhesions. The specific effect of talin proteolysis ...

New Penn Medicine research has found that elevated levels in the blood of the brain-enriched protein calpain-cleaved αII-spectrin N-terminal fragment, known as SNTF, shortly after sports-related ...