Lysine acetoacetylation (Kacac) was recently identified as a new histone mark. However, regulatory elements, substrate proteins, and epigenetic functions of Kacac remain unknown, hindering further ...

A comprehensive proteomic analysis has identified 139 Kacac sites on 85 human proteins. Bioinformatics analysis of Kacac substrates and RNA-seq data reveals the broad impacts of Kacac on diverse ...

This induces robust contractility of cytoskeleton structures to further transmit biomechanical alternations into nuclei by regulating Hippo-Yes associated protein (YAP) signaling pathway between ...

The preclinical models have provided the necessary biological substrate to ... by degrading membrane proteins such as glutamate receptors and transporters and can also modulate the function of protein ...

Department of Pharmaceutical Chemistry, University of California San Francisco, San Francisco, California 94158, United States Department of Cellular & Molecular Pharmacology, University of California ...

Calpain is a family of calcium-dependent cysteine proteases that is involved in many biological processes, such as signal transduction, cytoskeleton remodeling, and protein turnover ... identifying ...

antifreeze proteins, bacterial adhesins, and calpain enzymes. Dr. Davies is the first recipient from Queen’s to receive the Science Publishing Investigator Award. The award lecture will be given by Dr ...

We thank Justin Rettenmaier, Zachary Hill, Amy Weeks, Matthew Ravalin, Rebecca Levin, Julia Seaman, and Nicholas Agard for helpful discussions and technical help. We are grateful to Julie Zorn, Yinyan ...

New Penn Medicine research has found that elevated levels in the blood of the brain-enriched protein calpain-cleaved αII-spectrin N-terminal fragment, known as SNTF, shortly after sports-related ...

17 Suc-Leu-Leu-Val-Tyr-7-amino-4-methyl-coumarin (AMC; Sigma), was used as calpain substrate. Protein extracts (25 µg) were added to 20 µmol/L AMC in 300 µL Tris-buffered saline. AMC release was ...

Calpain expression is altered during tumorigenesis, and the proteolysis of numerous substrates, such as inhibitors of nuclear factor-κB (IκB), focal adhesion proteins (including, focal adhesion ...