Specifically, calpain-1 and calpain-2 have been linked to tumorigenesis ... Efforts are underway to develop calpain-specific inhibitors that could potentially block the progression of aggressive ...

As an example, Atg5 is an essential autophagy inducer, yet it can be cleaved by calpain cysteine proteases to lose its pro-autophagy effects and become a pro-apoptotic molecule. Beclin-1 (or its ...

Treatment of NLO with a DPR1 inhibitor, Mdivi-1 resulted in the improvement of morphology and the decreased expression of fibrosis-related markers, Col1a1 and Acta2. In addition, treatment of NASH ...

The RNA inhibitor olpasiran significantly reduces a type of "bad cholesterol" that's associated with a high risk of ...

Analysis by Mount Sinai researcher from First-of-its kind global trial could lead to future therapies to prevent deadly ...

AceLink Therapeutics, Inc., a clinical-stage biotech company developing next-generation oral substrate reduction therapies (SRTs), presented interim d ...

Perioperative chemotherapy with either S-1 or 5-fluorouracil plus oxaliplatin and docetaxel for locally advanced gastric or gastroesophageal junction adenocarcinoma: A prospective trial and matched ...

A national study seeking more effective treatment for deadly metaplastic breast cancer has identified two inhibitor drugs with the potential to interrupt disease progression.

The authors used the U.S. Department of Veterans Affairs databases to build a cohort of people with diabetes who initiated a GLP-1 RA and compared them to patients initiating sulfonylureas, dipeptidyl ...

It is the second drug in the PD-1/PD-L1 inhibitor class to be cleared in a subcutaneous injection form by the FDA after Roche's Tecentriq Hybreza (atezolizumab and hyaluronidase) – which got a ...

Scientists have discovered an antibody treatment that may help prevent both muscle loss and bone density loss in people using ...

The researchers proved if they therapeutically target the protein Apex1 with chemical inhibitors to either turn it off or remove it completely, then this could be a highly effective way to block ...