In summary, our flow cytometric analysis reveals upregulation of markers for tissue residency and effector function of T cells specifically in the retina/RPE/choroid complex of Cx3cr1 mice. Aging of ...

When the researchers specifically deleted the Cx3cr1 gene from their C57BL/6J mice, they saw that plaque build-up ceased to occur after aspartame feeding. These results point to CX3CL1’s role in ...

Gene-engineered immune cell therapies have partially transformed cancer treatment, as exemplified by the use of chimeric antigen receptor (CAR)-T cells in certain hematologic malignancies. However, ...

Microglia, the brain’s resident myeloid cells, play central roles in brain defense, homeostasis, and disease. Using a prolonged colony-stimulating factor 1 receptor inhibitor (CSF1Ri) approach, we ...

Adult-born granular cells (abGCs) in microglia-depleted mice have lower spine density, but not spine size, compared to abGCs in WT control mice. Together these findings suggest that microglia have ...