The CRISPR system has transformed many research areas, including cancer and immunology, by providing a simple yet effective genome editing system. Its simplicity has facilitated large-scale ...

Peer ReviewDownload a summary of the editorial decision process including editorial decision letters, reviewer comments and author responses to feedback. During somatosensory neurogenesis, neurons are ...

Cas9 endonuclease is bound by the mature crRNA–tracrRNA complex during interference, and it is further directed to cleave foreign DNA that has a complementary 20-nucleotide crRNA sequence before the ...

This manuscript reports important findings that the methyltransferase METTL3 is involved in the repair of abasic sites and uracil in DNA, mediating resistance to floxuridine-driven cytotoxicity. The ...

Pyogenes, the Edit-R platform comprises the three components required for gene editing in mammalian cells: (1) A plasmid encoding Cas9 nuclease, (2) a chemically-synthesized trans-activating RNA ...