Treated with an individualized gene-editing therapy that corrects mutations directly on the genome, a patient shows improvement from a rare metabolic disease.

In the study, "Targeting the SHOC2–RAS interaction in RAS-mutant cancers," published in Nature, researchers conducted a ...

Yet others, called base editors, change one letter of the DNA code to another. So why do we call it CRISPR? Cas proteins are used by bacteria to destroy viral DNA. They add bits of viral DNA to ...

Besides harnessing endogenous CRISPR-Cas systems to engineer human-associated microbes ... highlighting the approach’s potential to screen for bacteria amenable to genome editing without the need to ...

CRISPR-Cas systems are prokaryotic immune systems that confer resistance to foreign genetic elements such as plasmids and phages. CRISPR-Cas systems have been exploited for targeted genome editing.

Researchers have been working to find CRISPR/Cas nucleases with greater specificity ... a GFP activation expression reporting ...

CRISPR-Cas9 genome editing exploits the CRISPR-Cas system to modify a genome in a targeted manner. Guided by RNA, the Cas9 endonuclease breaks DNA at a target sequence. Imprecise repair of the ...

Cas9, the first Cas protein repurposed for cutting DNA, introduces double-strand breaks that recruit DNA repair machinery. Despite its successes, the CRISPR-Cas9 system has several limitations, ...

The medical promise of CRISPR gene editing can be seen most easily in current research on oral cancer, which affects more than 50,000 Americans every year. An increasing challenge in the treatment ...

Register now for free to discover the promise of CRISPR Cas 9 that extends beyond medical treatment. It can also be used to study genetic functions or to develop pest and disease resistant ...

In the study, "Targeting the SHOC2–RAS interaction in RAS-mutant cancers," published in Nature, researchers conducted a genome-wide CRISPR screen to identify genetic dependencies associated with ...