Machine learning models have seeped into the fabric of our lives, from curating playlists to explaining hard concepts in a ...

But zinc fingers, which cost US$5,000 or more to order, were not widely adopted because they are difficult to engineer and expensive, says James Haber, a molecular biologist at Brandeis University in ...

The CRISPR-Cas system has significantly improved over traditional gene editing techniques, such as transcription activator-like effector nuclease and zinc-finger nucleases, by providing an easily ...

there are several potential disadvantages in comparison with CRISPR/Cas9 system. For example, there is no straightforward and easy way to construct zinc finger domains to bind a comprehensive ...

Ichikawa notes that zinc-finger editing offers a potentially safer alternative to CRISPR, a key gene-editing technology with applications that range from finding new ways to kill cancer cells to ...

“I think this system levels the playing field for zinc fingers and CRISPR,” said Kim, who is also a professor of molecular genetics and computer science at U of T. “CRISPR is very ...

Scientists have long seen their potential because they naturally bind with DNA, are less likely than CRISPR and related technologies to trigger an immune reaction, and are small enough to work with ...

Scientists have long seen the potential of zinc finger proteins because they naturally bind with DNA, are less likely than CRISPR and related technologies to trigger an immune reaction, and are small ...

The researchers used CRISPR and zinc fingers to repress NaV 1.7 and block pain signals in neurons in mice. Credit: A.M. Moreno et al., Science Translational Medicine (2021) “In managing any ...