A minimum of 3 positive founders will be delivered. To produce CRISPR/cas9-mediated gene indels to generate knock-out mice or rats. The investigator will provide or purchase the CRISPR gRNA(s). TGEF ...

Mayo Clinic's Precision Mouse Engineering Core in Minnesota produces CRISPR/Cas9-mediated knockout and point mutant mice for researchers.

(REUTERS) British scientists are testing cutting edge gene editing techniques in mice, by inserting a jelly fish gene that makes their skin green. The research uses CRISPR-Cas9, a gene editing ...

R esearchers at Beijing's Chinese Academy of Sciences have used the gene-editing technology CRISPR to create mice from two fathers. CRISPR is a powerful genetic editing tool that allows scientists ...

Adding to the list of issues that can occur with CRISPR, a team of researchers now reports a high frequency of unwanted duplications while engineering genetic insertions in mice. Worryingly to the ...

The paper L. Jubair et al., “Systemic delivery of CRISPR/Cas9 targeting HPV oncogenes is effective at eliminating established tumors,” Mol Ther, 27:2091–99, 2019. When the human papillomavirus enters ...

Metabolic dysfunction-associated steatohepatitis (MASH) is a liver disease that progresses without symptoms and is associated ...

In vivo treatment achieves genome editing and restores mice vision. Exploration of dsRNA interactome using the K1 antibody and functional studies using CRISPR-Cas9 knockout screening of these ...

This study presents an enhanced nuclease prime editor (uPEn) that significantly improves gene knock-in and knockout ...