This study identifies 53BP1 as an interaction partner of GMCL1 (a likely CUL3 substrate receptor). The study seeks to link this finding to regulation of the mitotic surveillance pathway and paclitaxel ...

The only gene-editing therapy currently on the market is a CRISPR–Cas9-based treatment for two blood disorders, sickle-cell ...

A CRISPR treatment seems to have been effective for a baby’s devastating disease, but it is not clear whether such bespoke ...

Gene-edited spiders had never been seen before. Then University of Bayreuth researchers used CRISPR Cas-9 to give spiders red ...

Using CRISPR in mice, they tested how leukemia cells reacted when specific genes were turned off. This showed which signals and pathways the leukemia cells depended on the most to thrive.

The CRISPR-led gene-editing revolution is set to begin next month in its first ever trial in humans. The small phase 1 trial, to take place in China, will be investigating the method’s safety ...

In­tel­lia’s CRISPR-based ther­a­py main­tained re­duc­tions in the lev­els of a mis­fold­ed pro­tein in the nerves of pa­tients with a rare dis­ease called transthyretin amy­loi ...

Here we describe the development of a flow cytometry-based assay to assess LRRK2 activity in individual cells and the generation of an EGFP-Lrrk2 knock-in reporter mouse to analyse cell ... generated ...