The acute toxic effects and shortened clinical course in this patient after transgene treatment precluded assessment of the safety and efficacy of the CRISPR–transactivator approach. Although ...

“My whole adult life up to that point I was pretty much a cancer patient." The treatment she received uses “CRISPR gene editing” to create an individualized treatment for Stage 4 colorectal ...

CRISPR-Cas systems are prokaryotic immune systems that confer resistance to foreign genetic elements such as plasmids and phages. CRISPR-Cas systems have been exploited for targeted genome editing ...

CRISPR-Cas9 genome editing exploits the CRISPR-Cas system to modify a genome in a targeted manner. Guided by RNA, the Cas9 endonuclease breaks DNA at a target sequence. Imprecise repair of the ...

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