On May 12, 2025, the U.S. Court of Appeals for the Federal Circuit issued a long-awaited decision in Regents of the University of California v.

Interference No. 106,115 was the second interference between UC and Broad over patent rights to CRISPR-Cas9 technology in eukaryotic cells. The first interference concluded in 2018 after an appeal ...

A baby born with a rare and devastating genetic condition has become the first person ever to be successfully treated with a personalized CRISPR therapy. After receiving three doses of the therapy ...

Collaborating with CRISPR-Cas9 co-inventor Jennifer Doudna and Jill ... Successful editing produced a clear visual marker—affected areas turned white, including seedlings, confirming the edits ...

Nexiguran ziclumeran (nex-z) is an investigational therapy based on CRISPR-Cas9 (clustered regularly interspaced short palindromic repeats and associated Cas9 endonuclease) targeting the gene ...

optimized several parameters for single cell culturing and established an automated workflow for CRISPR/Cas9-based genome editing. When validated with a variety of genetic backgrounds and target genes ...

Here, we systematically profiled the factors that regulate protein stability of wild-type and mutant p53 using marker-based genome-wide CRISPR ... FVBN background, a generous gift of Sean Egan, The ...

Scientists from Zhejiang University have developed a novel delivery vehicle for CRISPR-Cas9 that is more effective than lipid nanoparticles (LNPs) in treating lung cancer. Rapid liquid nitrogen ...

For a decade, leading academic institutes and their associated companies fought a bruising, headline-grabbing fight over who held patent rights to CRISPR-Cas9, the revolutionary genome editing tool.

To date, no standardized protocols exist to transfect RNPs to soybean protoplasts through electroporation with reasonable mutation efficiency, which would greatly facilitate the CRISPR/Cas9 system to ...

The gene editing technique CRISPR/Cas9 has allowed researchers to make precise and impactful changes to an organism's DNA to fix mutations that cause genetic disease. However, the CRISPR/Cas9 ...

broad-host-range CRISPR-Cas9 delivery tool. Please introduce yourself, tell us about your career background, and provide insight into what has inspired your career to date? Hiya! My name is David ...