News

No-Moat Intellia's Gene-Editing Pipeline Looks Promising for Long-Term, Risk-Tolerant Investors
Intellia has leveraged its expertise in Crispr/Cas9 gene editing to advance a pipeline of in vivo and ex vivo therapies for diseases with high unmet medical needs. We believe Intellia's proprietary ...
Study reveals factors that drive efficient, precise editing and hidden DNA repair
Researchers at the Max Planck Institute for Evolutionary Anthropology have addressed a longstanding challenge in CRISPR ...
C&EN5d
Polyethylenimine-Functionalized Carbon Dots for Delivery of CRISPR/Cas9 Complexes
Cellular and Molecular Research Center, Iran University of Medical Sciences, Tehran 1449614535, Iran Department of Medical Nanotechnology, Faculty of Advanced Technologies in Medicine, Iran University ...
Science News6d
Personalized gene editing saved a baby, but the tech’s future is uncertain
The personalized CRISPR treatment could be the future of gene therapy, but hurdles remain before everyone has access.
Technology Networks6d
Novel CRISPR Tool Offers Safer, More Efficient Genome Editing
A study introduces a CRISPR model that predicts gRNA activity more accurately using chemically synthesized gRNAs. The model ...
AHA/ASA Journals7d
Disruption of cTnT-Mediated Sarcomere–Mitochondrial Communication Results in Dilated Cardiomyopathy
BACKGROUND: Dilated cardiomyopathy (DCM) is substantially influenced by genetic factors. Sarcomere function is intricately associated with other organelles, particularly the reciprocal regulation ...
Technology Networks13d
SMART Templates Break CRISPR’s PAM Barrier With 10× Editing Reach
Scientists have developed SMART (silently mutate and repair template), a strategy that dramatically expands the editable ...
Mirage News13d
ALS Research Unveils Path for Early Treatment
Using the gene scissors CRISPR and stem cells, researchers at Stockholm University and the UK Dementia Research Institute (UK DRI) at King's College ...
eLife15d
Structural and dynamic impacts of single-atom disruptions to guide RNA interactions within the recognition lobe of Geobacillus stearothermophilus Cas9
of the CRISPR Cas9 enzyme from G. stearothermophilus (GeoCas9). Using truncated and full-length constructs they assess the impacts of two different point mutations have on the redistribution and ...
JD Supra15d
Federal Circuit Revives CRISPR-Cas9 Patent Priority Dispute
Interference No. 106,115 was the second interference between UC and Broad over patent rights to CRISPR-Cas9 technology in eukaryotic cells. The first interference concluded in 2018 after an appeal ...
News Medical15d
Study uncovers common trigger across gene mutations that cause ALS
The researchers used the gene scissors CRISPR/Cas9 to introduce various ALS-causing mutations into human stem cells, called iPS cells. From these, motor neurons, the nerve cells that are lost in ...
eLife15d
Structural and dynamic impacts of single-atom disruptions to guide RNA interactions within the recognition lobe of Geobacillus stearothermophilus Cas9
While the mutations studied do not lead to significant changes in GeoCas9 cleavage activity, the study provides convincing evidence for the role of allosteric mechanisms and interdomain communication ...