A temporally resolved CRISPR-Cas9 screen reveals DAC-induced DNA damage drives trans-cell cycle cytotoxicity that depends on ...

In December 2023, through the development efforts of CRISPR Therapeutics and Vertex Pharmaceuticals, their decades-long ...

CRISPR-Cas9 is a precision genome editing technology that can knock out, activate or fine-tune the expression of individual genes. We provide access to CRISPR KO (knockout), CRISPRi (interference ...

Researchers have revealed new details about the CRISPR-Cas5-HNH/Cascade complex, a variant of the type I-E CRISPR-Cas system, ...

CRISPR technology has radically transformed genetic research, and at the forefront of this transformation is CRISPR screening ...

When the CRISPR Cas9 protein is added to a cell along with a piece of guide RNA, the Cas9 protein hooks up with the guide RNA and then moves along the strands of DNA until it finds and binds to a ...

This study presents an optimized CRISPR-Cas12a system for large-scale genetic screening, revealing critical genes involved in ...

Horizon has created a library of ready-made isogenic human cell line pairs edited using CRISPR-Cas9 technology. With 10,000 gene targets available — 3,000 of them off-the-shelf — the knockout ...

In the spring, five patients with sickle cell disease began treatment with Casgevy, the first FDA-approved CRISPR-Cas9 gene editing treatment. The therapy—which involves removing blood stem ...

Gene knockout models involve the deliberate inactivation ... protein 9 systems are common gene-editing technologies, with ...

CRISPR Therapeutics AG is a gene editing company, which engages in the development of transformative gene-based medicines for serious diseases using its proprietary CRISPR/Cas9 platform.

Monoallelic loss of PTEN and ARID1A is identified in normal colonic epithelium. The resulting haploinsufficient phenotypes ...