A successful CRISPR knockin isn’t just about inserting DNA. It’s about ensuring that edit stays functional and reliable over ...

Systematic CRISPR screening with Cas12a and Cas9 systems identified 1236 genetic interactions ... pairs suggests that if a disruption in zinc homeostasis occurs due to the knockout of one transporter, ...

Natural products (NPs), with their multi-target and multifaceted properties, present promising candidates for new drug development. This review delineates the anti-fibrotic pathways and targets of ...

Tools for diversifying genomic DNA in mammalian cells have long relied on base editors making C to T or A to G substitutions. Here, authors use RNA-guided DNA polymerases (EvolvR) to evolve ...