You may have seen it in the news recently: a baby in Pennsylvania with a rare genetic disorder was healed with a personalized ...

BACKGROUND: Dilated cardiomyopathy (DCM) is substantially influenced by genetic factors. Sarcomere function is intricately associated with other organelles, particularly the reciprocal regulation ...

The viability of these pairs suggests that if a disruption in zinc homeostasis occurs due to the knockout of one transporter ... we conducted an orthogonal screen using CRISPR-Cas9 (Cas9-SLCxSLC).

Peer ReviewDownload a summary of the editorial decision process including editorial decision letters, reviewer comments and author responses to feedback. TP53 mutations in AML confer resistance to CAR ...

However, mice implanted with human tumor cells that have not been ... The team used a molecular tool called CRISPR-Cas9 to knock out genes researchers believe could play a role in making tumors ...

In this valuable study, the authors demonstrate that TCF7L2 plays a role in the pathogenesis of cachexia in a mouse model of GI cancer. The results are solid, although future studies will need further ...