This valuable study reports on the critical role of ANKRD5 (ANKEF1) in sperm motility and male fertility. However, the supporting data remain incomplete. This work will be of interest to biomedical ...

Northwestern Medicine investigators have developed a new avenue to reprogram compromised immune cells to act against tumors, ...

This study presents an optimized CRISPR-Cas12a system for large-scale genetic screening, revealing critical genes involved in ...

This changed with the development of Clustered Regularly Interspaced Short Palindromic Repeats (CRISPR)/Cas9 genome editing ... system is the ‘gold standard’ of creating conditional knockout alleles ...

Methods We applied empagliflozin treatment to lupus-prone MRL/lpr mice to explore the renal protective potential of SGLT2 inhibitors. An SGLT2 knockout monoclonal podocyte cell line was generated ...

CRISPR technology has radically transformed genetic research, and at the forefront of this transformation is CRISPR screening ...

For the first time, scientists have created a bi-paternal mouse – that is ... To address these limitations, the team used a CRISPR/Cas9-based gene editing technology to target 20 genes ...

Monoallelic loss of PTEN and ARID1A is identified in normal colonic epithelium. The resulting haploinsufficient phenotypes ...

This important study examines the role of pericytes in patterning the zebrafish blood-brain barrier (BBB) and controlling its permeability. Using pdgfrb mutant zebrafish models lacking brain pericytes ...

CRISPR-Cas9 genome editing exploits the CRISPR-Cas ... Now, an in vivo protocol facilitates screens in mouse brain, using adeno-associated virus with transposon-based delivery of the CRISPR ...