Scientists from Zhejiang University have developed a novel delivery vehicle for CRISPR-Cas9 that is more effective than lipid nanoparticles (LNPs) in treating lung cancer. Rapid liquid nitrogen ...

Subsequently, DNA repair pathways like non-homologous end joining (NHEJ) or homology-directed repair bring the Cas9 and sgRNA together to ultimately modify the genome. The incorporation of CRISPR ...

In research published in Nature Catalysis, scientists at Florida State University produced the first high-resolution, time-lapsed images showing magnesium ions interacting with the CRISPR-Cas9 enzyme ...

In research published in Nature Catalysis, scientists at Florida State University produced the first high-resolution, time-lapsed images showing magnesium ions interacting with the CRISPR-Cas9 ...

Whilst genome editing with CRISPR-Cas9 is effective, it runs the risk of off-target effects and excessive mutations, which can lead to toxicity. To reduce the likelihood of these occurring, ...

Researchers are working to reveal potential threats to the efficacy of CRISPR/Cas9 gene editing, even when it appears to be working as planned. A Rice University lab is leading the effort to ...

The CRISPR/Cas9 gene editing system aims to do just that. Researchers have been modifying and improving the technique since it was developed about a decade ago, and it has even been used in the clinic ...

Princeton and MIT gene editing pioneers uncover clues for improving CRISPR and other tools When Cas9 encounters a mismatch in 18 through 20, it forms a fingerlike linear structure (cyan in image ...

CRISPR-Cas9 induces large structural variants at on-target and off-target sites in vivo that segregate across generations. Nature Communications , 2022; 13 (1) DOI: 10.1038/s41467-022-28244-5 Cite ...

A comprehensive study headed by researchers at Sanford Burnham Prebys has shown that gene editing—specifically gene knockout (KO)—using CRISPR-Cas9 technology can favor cells with mutated ...

This method, which is still being researched, uses the famous Nobel Prize winning gene-editing technology, CRISPR-Cas9. Scientists from the University of Sherbrooke in Canada used the technology ...

By Katherine J. Wu A powerful gene-editing tool called Crispr-Cas9, which this month nabbed the Nobel Prize in Chemistry for two female scientists, can cause serious side effects in the cells of ...