The team first focused on a structural feature of the CRISPR Cas9 protein that is key to its success as a genome-editing tool; this structural feature is responsible for binding to the enzyme’s RNA ...

Advances in the gene-editing technology known as CRISPR-Cas9 over the past 15 years have yielded important new insights into the roles that specific genes play in many diseases. But to date this ...

CRISPR-Cas9 genome editing exploits the CRISPR-Cas ... Here, the authors have designed and optimized circular guide RNA (cgRNA) for Cas12f, which significantly improves the efficiency of gene ...

A team of researchers at Karolinska Institutet has developed a novel tool for genetic research. The study, published in ...

This protein can easily be programmed to find and bind to almost any desired target sequence, simply by giving it a piece of RNA to guide it in its search. When the CRISPR Cas9 protein is added to ...

CRISPR technology has revolutionised genetic engineering, offering unprecedented precision in DNA editing with vast implications for medicine, agriculture and conservation. Yet, its power demands ...

This study shows that RNA decay rather than the presence of premature termination codons triggers a TA-like response.

Advances in the gene-editing technology known as CRISPR-Cas9 over the past 15 years have yielded important new insights into ...

Advances in the gene-editing technology known as CRISPR-Cas9 over the past 15 years have yielded important ... But to date this technology — which allows scientists to use a “guide” RNA to modify DNA ...

Advances in the gene-editing technology known as CRISPR-Cas9 over the past 15 years ... which allows scientists to use a “guide” RNA to modify DNA sequences and evaluate the effects ...