Somatic hypermutation (SHM) of immunoglobulin variable (V) regions modulates antibody-antigen affinity is initiated by activation-induced cytidine deaminase (AID) on single-stranded DNA (ssDNA).

CRISPR-Cas9 is a powerful gene editing system that has revolutionized our ability to treat disease and probe the human genome. CRISPR has been used to edit the genomes of animals, plants, and microbes ...

Over the past decade, lipid nanoparticles (LNPs) have become a cornerstone in the field of nucleic acid delivery, with applications extending from vaccines ...

The global CRISPR Gene Editing Market is expected to grow at a significant rate ... For instance, researchers at Cold Spring Harbor Laboratory used CRISPR/Cas9 technology in June 2019 to create ...

Over the past decade, the gene-editing ... clear evidence of the successful knock-in of the gene sequence into a silk protein. “We have demonstrated, for the first time worldwide, that CRISPR ...

HG302’s developers have moved on to testing the treatment in humans as part of a multidose, dose-escalation study to understand the safety of CRISPR gene-editing therapy and its long-lasting ...

PALM SPRINGS, Calif. (KESQ) A portion of North Gene Autry Trail in Palm Springs was closed due to blowing sand and low visibility, Palm Springs Police said in a Sunday morning press release.

Targeting the intracellular immune checkpoint CISH with CRISPR-Cas9-edited T cells in patients with metastatic colorectal cancer: a first-in-human, single-centre, phase 1 trial. The Lancet ...

Mitochondrial diseases affect approximately 1 in 5,000 people worldwide, causing debilitating symptoms ranging from muscle weakness to stroke-like episodes. Some of these conditions result from ...

The treatment she received uses “CRISPR gene editing” to create an individualized treatment for Stage 4 colorectal cancer patients, as Dr. Emil Lou, the principal investigator of the clinical ...

From a translational perspective, the results from this first-in-human clinical trial have important implications, because they underline the feasibility of using CRISPR-Cas9-engineered TILs in ...