A “genetic surgery” or “interventional genetics” system for individualized treatments would be a marriage of drug development ...

Somatic hypermutation (SHM) of immunoglobulin variable (V) regions modulates antibody-antigen affinity is initiated by activation-induced cytidine deaminase (AID) on single-stranded DNA (ssDNA).

CRISPR-Cas9 is a powerful gene editing system that has revolutionized our ability to treat disease and probe the human genome ...

Gene drives are systems of biased inheritance that enhance a genetic element's ability to pass from parent organism to offspring. With the advent of new, more efficient, and targeted gene-editing ...

Over the past decade, the gene-editing ... clear evidence of the successful knock-in of the gene sequence into a silk protein. “We have demonstrated, for the first time worldwide, that CRISPR ...

Collaborating with CRISPR-Cas9 co-inventor Jennifer Doudna and ... CRISPR system that uses the tobacco rattle virus to deliver gene-editing tools directly to the germ cells, or the reproductive ...

Crispr Therapeutics is an emerging gene editing company focused on the development of Crispr/Cas9-based therapeutics ... and make sure their analysis is clear and in no way misleading or deceptive.

we are excited to have these tools utilized by the community and also apply this framework to other properties and enzymes in the genome editing repertoire." CRISPR-Cas9 enzymes can be used to ...

A new paper showcases the power of scalable protein engineering combined with machine learning to boost progress in the field of gene and ... the genome editing repertoire." CRISPR-Cas9 enzymes ...

In a new study published in Nature titled, “Custom CRISPR-Cas9 ... or thousands of novel Cas9 proteins. “We’re excited to share these enzymes with the genome editing community and to ...

At its heart, CRISPR is a gene-editing system that enables scientists to make precise alterations to an organism's DNA. The most widely adopted variant, CRISPR-Cas9, relies on two ... underscoring the ...

Advances in the gene-editing technology known as CRISPR-Cas9 over the past 15 years have yielded important new insights into the roles that specific genes play in many diseases. But to date this ...