The current pathophysiology of COPD encompasses three main characteristics: emphysema, chronic bronchitis and small airway disease. Macrophages and neutrophils are implicated in this process ...

With the earlier definition of chronic obstructive pulmonary disease (COPD), patients were essentially defined as having either chronic bronchitis or emphysema, with emphysema classified as a ...

Moving from patients to animal or cellular models and back represents an iterative process by which we can elucidate the intricate pathophysiology of asthma. Herein, we focus on the underlying ...

While several excellent reviews have been focused on CD44–HA signaling and its implications in cancer (3–12), this review focuses on both HA-independent (mainly) and HA-dependent functions of CD44 in ...