Vepdegestrant is an oral proteolysis-targeting chimera (PROTAC) estrogen receptor (ER) degrader that directly harnesses the ubiquitin–proteasome system. In this phase 3, open-label, randomized ...

The bitter taste receptors we have on our tongues are also found in other organs, including the gut. A new study has identified two specific receptors in the large intestine that are associated ...

After earning notoriety as the first cellular receptor isolated and mammalian lectin identified, the Ashwell-Morell receptor's functions in our bodies eluded scientists for more than 30 years.

Researchers confirm and explore the role of estrogen-related receptors in regulating energy production in muscle cells during exercise. The findings indicate that developing a drug to boost ...

FcRn protects IgG and albumin from catabolism, transports IgG across the placenta, and regulates IgG function. Blocking or augmenting FcRn can decrease autoimmune antibodies and enhance drug delivery.

MCARH109 is a first-in-class G protein–coupled receptor, class C, group 5, member D (GPRC5D)-targeted chimeric antigen receptor (CAR) T-cell therapy for patients with relapsed/refractory multiple ...

Engineered Receptors Help the Immune System Home in on Cancer UCSF and University of Washington researchers developed synthetic receptors on the surface of immune cells that could make cancer ...

CCR4 expression in Tregs is critical for limiting proinflammatory Th1 cell-mediated immune responses and atherosclerosis by maintaining the suppressive and migratory functions of Tregs.

Rationale:Studies in cultured endothelium implicate that lectin-like oxidized low-density lipoprotein receptor-1 (LOX-1) or Fcγ receptor II (CD32) contributes to the proatherogenic effects of ...

The expression of CD32 in HIV-reservoir cells prevents the binding of specific anti-HIV antibodies conferring resistance to NK cell-mediated death, and gives the cell the potential to proliferate in ...

FcγRII (Fc gamma receptor II, CD32) FcγRII receptor is the one that is broadly expressed on hematopoietic cells among FcγRs. FcγRII includes FcγRIIA, FcγRIIB and FcγRIIC isoforms.

Finding sensors on nerve cells that detect temperature and pressure nets California scientists David Julius and Ardem Patapoutian a Nobel Prize.