Alternative biofluids for protein biomarker discovery in ALS are urine and saliva. The advantage of using these fluids is that their collection is minimally invasive. On the other hand ...

Denali Therapeutics’ amyotrophic lateral sclerosis (ALS ... assessing the drug's effect on neurofilament light (NfL)—a biomarker of neuronal damage—as well as specific subgroups of patients ...

“Phospho-tau in blood is not as specific as everyone would like to think. … And for ALS patients, it is actually an additional new biomarker,” said Markus Otto of Martin-Luther-University ...

SDTC is a well-established electrophysiological biomarker of peripheral motor excitability related to ALS, where elevation of SDTC has been clinically shown to predict faster disease progression ...

while correctly ruling out ALS in over 80% of non-ALS cases. The other biomarkers performed poorly, with accuracy rates ...

Tania Gendron, PhD, speaks to the present challenges for translating biomarker discoveries to clinical practice and offers ...

Preclinical data with the investigational gene therapy INS1202 show improvements in survival and motor performance in ALS.