Nervous necrosis virus typically enters host cells via endocytosis, but it can also enter via a process called macropinocytosis.

MS patients on B-cell depleting therapies are still protected against COVID-19 risk due to greater anti-viral T-cell activity, a study found.

Beacon Discovery™ enables real-time functional investigation of single cells. Powered by optofluidic technology, it allows ...

B-cell acute lymphoblastic leukemia (B-ALL) is the most common cancer in children, accounting for around 85% of pediatric ...

This study identifies 53BP1 as an interaction partner of GMCL1 (a likely CUL3 substrate receptor). The study seeks to link this finding to regulation of the mitotic surveillance pathway and paclitaxel ...

Study in mice shows how a host-elicited factor benefits gut immunological homeostasis by selectively targeting commensal ceramide molecules.

Chimeric antigen receptor (CAR) T cells targeting CD19 have transformed the treatment of B-cell cancers, but many patients do not have long-term remission. We designed an anti-CD19 enhanced ...

When it comes to getting the most out of a vaccine, arm consistency can make a difference. Some studies suggest that getting a booster in the same arm as the initial shot can boost the immune system’s ...

Best known for producing antibodies, B cells also guide other immune cells, specifically CD8 T cells, teaching them how to mount lasting defenses after vaccination. The study was recently ...

Clinical data on a CD19-directed CAR-T cell therapy in lupus has sent interest in the depletion of B cells to treat autoimmune and inflammatory diseases into overdrive in recent years. Companies ...

Three patients had nonrelapse mortality events; all occurred in the setting of ongoing B-cell aplasia. The final LV20.19 CAR products were enriched for higher percentages of T-SCM /T-naïve cells and ...

A promising lead has emerged from examining the interaction between the tumor and immune cells, including CAR-T cells. It turns out that B-ALL tumors may take advantage of the body’s natural ...