The presence of autophagic structures in dying cells, in diverse organisms has implicated autophagy in the cell death process. Cell death is of paramount importance both for the development and ...

Scientists now believe that autophagy itself can trigger cell death, although it may be a rare and highly specialized event. Autophagy is certainly known to play a role when tissues are formed ...

Additional mechanisms may include a role for autophagy in the regulation of cell death and proliferation, as shown in models of cardiac and lung diseases. In cancer, autophagy may prevent ...

However, FOXO3a not only maintains autophagy equilibrium but also controls the gene that makes a protein called PUMA - and PUMA drives the cell death known as apoptosis. Putting it all together ...

Some of the different types of programmed cell death (PCD) include necroptosis, pyroptosis, apoptosis, and autophagy. Recent studies have provided a better understanding of the mechanisms ...

Autophagy also kills the cells under certain conditions. These are form of programmed cell death (PCD) and are called autophagic cell death. Programmed cell death is commonly termed apoptosis.

Impact of obesity and adiponectin signaling in patients with renal cell carcinoma: A potential mechanism for the obesity paradox.

A deeper understanding of osteosarcoma, the most common primary malignant bone tumor affecting children and adolescents, is ...

However, cell death was not inhibited by inhibitors of the other types of PCDs. Hence, they ruled out autophagy, necroptosis, and apoptosis, confirming that paraptosis is a major PCD pathway ...

Cells use a variety of programmed cell death mechanisms to maintain homeostasis through cellular self-destruction, including apoptosis, necroptosis, and pyroptosis. Elina is a PhD candidate at the ...

Understanding the molecular mechanisms driving osteocyte death is crucial to developing ... which drives excessive autophagy and ferritin degradation, leading to intracellular iron overload ...