Broad Institute researchers have developed a way to edit the genetic sequences at the root of Huntington's disease and ...

Other measures of ataxia also force the animal to move, including the balance beam, which scores hind paw slips from the beam as mice traverse it 2. Some animals stop moving during this test ...

A targeted therapy developed by scientists at University of Utah Health slows the progression of a condition in mice that mimics a rare disease called ataxia. In a parallel collaborative study, led by ...

University of Utah scientists found that antisense drugs reversed symptoms in mouse models of ataxia and amyotrophic lateral sclerosis. Ataxia, a rare neurodegenerative disease characterized by a ...

In addition, the study reports that stimulating mice with early-stage ataxia showed the most dramatic improvements. These and other findings, published in the journal Nature Communications, provide ...

In 2019, Mootha's team found that continuously exposing young mice with Friedreich's ataxia to 11% oxygen, as opposed to 21% at sea level, early in the disease prevented ataxia.

A new study describes a new genetic mutation as an additional cause of ataxia in humans and mice. The mutation, in the gene CAPN1, affects the function of the enzyme calpain-1 and causes abnormal ...

Further investigations in ataxia mouse models confirmed that CF degeneration leads to disruptions in cerebellar frequency, ...

4 “From there, the idea was, first, looking in another mouse model,” Salazar said. “And also trying to unravel a little bit of the cellular mechanisms that were at play here.” To model ataxia, the ...

Mice with Kcnj10 deletions became dehydrated, with definitive evidence of renal salt wasting. Mutations in KCNJ10 cause a specific disorder, consisting of epilepsy, ataxia, sensorineural deafness ...

A targeted therapy developed by investigators at University of Utah Health slows the progression of a condition in mice that mimics a rare disease called ataxia. In a parallel collaborative study ...