For example, Compass Pathways’ COMP360 psilocybin therapy, the fast-acting ketamine derivative RR-HNK and NRx Pharmaceuticals’ combination of an NMDA receptor modulator and 5-HT2a receptor ...

Hot flashes in menopause can cause areas of the face, neck, or chest to flush, triggering a rosacea flare-up. Oral and topical medications can often help you manage symptoms. Rosacea is a chronic ...

Expert Rev Neurother. 2013;13(1):23-36. The focus of brain research related to psychotic disorders has in recent years shifted from focal pathology to disturbances in connectivity and circuits ...

This patent highlight describes a series of novel 2-pyrrolidone derivatives that act as negative allosteric modulators (NAMs) of GluN2B-containing N-methyl-d-aspartic acid receptors (NMDARs). These ...

The review covered other hormones and endocrine actors, too, including alpha-melanocyte stimulating hormone (α-MSH), oxytocin, endocannabinoids, and peroxisome proliferator-activated receptor ...

Department of Pharmaceutical and Medicinal Chemistry, Institute of Pharmaceutical Sciences, University of Tuebingen, Auf der Morgenstelle 8, Tuebingen 72076, Germany IFIT Cluster of Excellence EXC ...

Enclomiphene is one of the two stereoisomers of clomiphene citrate (CC), a non-steroidal selective estrogen receptor modulator (SERM). It acts as either an estrogen receptor agonist or antagonist ...

Over the last years non-alcoholic fatty liver disease (NAFLD) has grown into the most common chronic liver disease globally, affecting 17-38% of the general population and 50-75% of patients with ...

G protein-coupled receptors (GPCRs) are the target of hundreds of approved drugs. Although these drugs were designed to target individual receptors, it is becoming increasingly apparent that GPCRs ...