A preclinical study from scientists at Scripps Research finds that a drug already FDA-approved for treating inflammatory conditions may help reduce both alcohol intake and pain sensitivity-two issues ...

A 2021 study compared Aimovig treatment with Topamax (topiramate), an anti-seizure drug used for migraine prevention, and found it effective with few side effects. Still, more research is needed, and ...

Combination therapy did not provide a benefit in the overall cohort of patients with recurrent ovarian cancer or when patients were evaluated according to BRCA status. Combination treatment with a ...

Angiogenesis is a complex, combinatorial process that is regulated by a balance between pro- and anti-angiogenic molecules 1. This balance is disturbed in the setting of pathological angiogenesis ...

Shanghai Frontiers Science Center for Drug Target Identification and Delivery, School of Pharmaceutical Sciences, Shanghai Jiao Tong University, Shanghai 200240, China State Key Laboratory of ...

SSc fibroblasts suppress angiogenesis ... of a protein transport inhibitor GolgiPlug (BD Biosciences) for 12 hours according to manufacturer’s instructions. The cells were then stained on ice with ...

As2O3 has a significant anti-angiogenic effect on the synovium of RA-FLS ... Hypomethylation of pro-angiogenesis genes (e.g., VEGFA, ANGPT2) in RA VEC amplifies synovial angiogenesis. HDAC inhibitors ...

To inspire future developments, we outline key directions to expand the horizons of photodynamic nanomedicine in targeting tumor angiogenesis and metabolism. Develop stimuli-responsive nanocarriers ...

Key Findings: CS2011 (an EGFR/HER3 bispecific antibody), composed of anti-EGFR and anti-HER3 arms with balanced affinity, effectively and synergistically inhibits EGFR/HER3 downstream signaling ...

Destroying blood vessels in highly vascular, solid cancers—also known as anti-angiogenesis therapy—reduces tumor burden initially but also increases tumor hypoxia which fosters immune escape and ...