A new way of thinking about Alzheimer's disease has yielded a discovery that could be the key to stopping the cognitive ...

Endogenous intracellular allosteric modulators of GPCRs remain largely unexplored, with limited binding and phenotype data available. This gap arises from the lack of robust computational methods for ...

Curcumin, a phenolic antioxidant extracted from the rhizomes of turmeric and other Curcuma species, possesses strong ...

Researchers at the University of São Paulo (USP) in Brazil have succeeded in showing, in an animal model, that the process of ...

The study is useful for advancing spatial transcriptomics through its novel regression-based linear model ... cells, representing 13 distinct cell types, within the mouse brain cortex, visualizing the ...

We have shown that obexelimab inhibits the phosphorylation of BTK, thereby interfering with BCR signalling. Objectives: The aim of this study is to examine the molecular effects of obexelimab on B ...

Herein, we report that our organoid model contains all relevant epithelial cell types found in the colon. We show that SLE serum stimulation can induce alterations in the expression profile, which are ...

Moreover, fibrosis in scleroderma skin grafts was alleviated by engraftment with unmatched allogeneic hematopoietic stem cells. Mechanistic studies supported a trans-signaling model whereby CD4 ...

Macrophages and macrophage-like VSMCs both assume the roles of a signaling sender and receiver, showing the highest communication capability. T cells acted more as senders, while B cells acted as ...

NMII inhibition by cIIAKO did not affect B-cell spreading on PLB but delayed B-cell contraction and altered BCR ... of NMII in BCR signaling utilizing GFP-NMIIA transgenic mice and a partial ...

Infection of primary B cells by EBV relies on the EBV-encoded protein LMP2A, which is currently thought to mimic BCR signaling. We revise this model based on systematic comparison of BCR and LMP2A ...