Thalassemia occurs when there is a mutation or deletion in the genes that code for these globin chains. Depending on which chain is affected, it is classified as: Alpha-thalassemia: Caused by ...

“A person normally inherits four alpha globin genes, two from each parent ... Multiplex Ligation-dependent Probe Amplification, which detects deletions or duplications in gene copies “These tests are ...

Researchers at the University of California, Davis, have deleted a cluster of genes in wheat that generates ... gamma radiation to target and delete alpha-gliadins, which can cause severe ...

Three common α-globin gene deletions, three mutations, and 17 mutations in the β-globin gene were detected using PCR-flow fluorescence hybridization. Next-generation sequencing (NGS) and CNVplex ...

We sought to evaluate the impact of alpha globin gene deletions on NO signaling and unexpectedly found human arteries use not only alpha but also beta globin to regulate eNOS. The eNOS-hemoglobin ...

We sought to evaluate the impact of alpha globin gene deletions on NO signaling and unexpectedly found human arteries use not only alpha but also beta globin to regulate eNOS. Hemoglobin is expressed ...

The different types of thalassemia develop due to genetic mutations or deletions (where genetic code is missing) in the genes that support alpha and beta globin production. Abnormalities in these ...

In this study, researchers designed an innovative model by deleting alpha globin genes in adult mice using a lipid nanoparticle (LNP) embedded within mRNA that induced the deletion of the alpha globin ...

Alpha-globin and beta-globin protein chains make up hemoglobin. Changes in the alpha- or beta-globin genes that provide instructions for these proteins can lead to thalassemia. Four genes comprise ...

Hemoglobin H Disease is a more severe form of alpha thalassemia caused by the deletion of three alpha globin genes (inherited from both parents). Individuals with hemoglobin H disease may experience ...

People with alpha-thalassemia have a deletion of one or more of their α globin-producing genes. (1 missing) alpha-thalassemia carrier You’re a silent carrier with no significant symptoms.