The addition of β-adrenergic receptor antagonists to a medical regimen for heart failure that includes angiotensin-converting enzyme (ACE) inhibitors as background therapy has been associated ...

The crystal structure of a second G protein–coupled receptor sheds light on these key pharmaceutical targets. In contrast, β2AR and essentially all of the other GPCRs are present at very low ...

The 'fight or flight' hormone adrenaline — which is produced during times of stress — is an agonist of the β 2-adrenergic receptor (β 2 AR), a G-protein-coupled receptor (GPCR) that mediates ...

Finally there is decreased responsiveness to adrenergic receptor stimulation, a decreased reactivity to baroreceptors and chemoreceptors, and an increase in circulating catecholamines. These ...

Mice exhibit a well-documented circadian rhythm and ECG parameters comparable to humans, so the researchers pharmacologically blocked the SNS using the β-adrenergic receptor blocker, propranolol in ...

Ephedrine sulfate is a sympathomimetic amine that directly acts as an agonist at α-and ß-adrenergic receptors and indirectly causes the release of norepinephrine from sympathetic neurons.

adrenergic receptor blocking agent that slows the sinus rate and decreases AV nodal conduction. The β-blocking activity of metoprolol has been shown by reduction in heart rate and cardiac output ...

Propranolol reduces Parkinson’s tremor and motor cortex activity, suggesting a new therapeutic approach beyond stress ...