Finally, given the multiple immunological tasks coordinated by WASP through regulation of the actin cytoskeleton, pharmacological intervention in WASP-mediated signalling pathways could eventually ...

Paxillin's function in regulating remodelling of the actin cytoskeleton is also discussed (Fig. 1). Figure 1: Integrin and growth-factor signalling through paxillin, and interactions with the ...

The present study identifies a role for actin cytoskeleton organization in the posttranscriptional regulation of eNOS during cell growth and examines the relationship between the state of actin ...

This requires dynamic cellular signalling events that ensure homeostasis and plasticity ... We next set out to establish if the actin cytoskeleton mediates the cellular response to fluid pressure via ...

B cells detect foreign antigens through their B cell antigen receptor (BCR). The BCR, when engaged by antigen, initiates a signaling cascade. Concurrent with signaling is endocytosis of the BCR ...

The figure was created with www.biorender.com. T cells and B cells are the primary target cells of IL-21, and the expression of IL-21R on their cell membranes is upregulated following TCR and BCR ...

1Department of Microbiology, University of Pennsylvania, Philadelphia, Pennsylvania. 2Center for Cellular Immunotherapies, University of Pennsylvania, Philadelphia ...