BCR signaling plays a crucial role in the pathogenesis of CLL. 2,9,10 Activation of this pathway fosters an ideal leukemic microenvironment, promoting CLL cell proliferation and survival. 2 BCR ...

Implications for motility and transmission are discussed. This study directly visualises actin cytoskeleton in Plasmodium falciparum sporozoites under native conditions and investigates its structural ...

Medicinal Chemistry Research Group and National Drug Discovery and Development Laboratory, HUN-REN Research Centre for Natural Sciences, 2 Magyar tudósok krt, Budapest 1117, Hungary ...

Functional analyses support that this mutation specifically impairs Nef`s ability to stimulate PI3K/Akt/mTORC2 signalling. This important study suggests that the accessory viral protein Nef impairs B ...

Taken together, we provide computational and experimental support for interdependence between the F-actin ... the cytoskeleton using small molecules, based on the seminal study by Sachs et al., 2005 ...

Even activation and differentiation of follicular B-cells require NF-κB signaling. Additionally, NF-κB plays a role in the survival of activated B cells mainly due to stimulation through BCR (87).

The requirement of actin cytoskeleton integrity for productive T cell/APC encounter and for the assembly of key signaling networks has been established along with the characterization of the IS ...

During development, nerve cells establish precise networks of processes that provide the basis for nervous system functioning. To a large extent the organization of such neural networks is ...