Paxillin's function in regulating remodelling of the actin cytoskeleton is also discussed (Fig. 1). Figure 1: Integrin and growth-factor signalling through paxillin, and interactions with the ...

Finally, given the multiple immunological tasks coordinated by WASP through regulation of the actin cytoskeleton, pharmacological intervention in WASP-mediated signalling pathways could eventually ...

The present study identifies a role for actin cytoskeleton organization in the posttranscriptional regulation of eNOS during cell growth and examines the relationship between the state of actin ...

This requires dynamic cellular signalling events that ensure homeostasis and plasticity ... We next set out to establish if the actin cytoskeleton mediates the cellular response to fluid pressure via ...

Study of the genetics of rheumatoid arthritis (RA) began about four decades ago with the discovery of HLA-DRB1. Since the beginning of this century, a number of non-HLA risk loci have been identified ...

The figure was created with www.biorender.com. T cells and B cells are the primary target cells of IL-21, and the expression of IL-21R on their cell membranes is upregulated following TCR and BCR ...

aMRC Centre for Transplantation, King's College London, Great Maze Pond, London SE1 9RT, UK bBiostatistics and Health Informatics Department, Institute of Psychiatry, Psychology and Neuroscience, King ...

Edited by Ellen V. Rothenberg, California Institute of Technology, Pasadena, CA, and accepted by Editorial Board Member Neil H. Shubin February 17, 2017 (received for review July 26, 2016) ...