Paxillin's function in regulating remodelling of the actin cytoskeleton is also discussed (Fig. 1). Figure 1: Integrin and growth-factor signalling through paxillin, and interactions with the ...

Finally, given the multiple immunological tasks coordinated by WASP through regulation of the actin cytoskeleton, pharmacological intervention in WASP-mediated signalling pathways could eventually ...

Study of the genetics of rheumatoid arthritis (RA) began about four decades ago with the discovery of HLA-DRB1. Since the beginning of this century, a number of non-HLA risk loci have been identified ...