Here we use cryogenic electron microscopy to determine the structure of TbAQP2 from Trypanosoma brucei, bound to either the substrate glycerol or to the sleeping sickness drugs, pentamidine or ...

Fit-ligand is a computational algorithm that enables accurate modeling of multiple conformational states of ligands in X-ray crystallography and cryo-electron microscopy (cryo-EM).

Within each (A or B) subclass, receptor-ligand interactions are highly promiscuous and in vivo interactions likely occur where a receptor and ligand of the same subclass are co-expressed.

Tocopheryl acetate is a form of vitamin E that’s often found in skin care products and dietary supplements. Learn about its potential benefits and risks.

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Ligand-Exchange Routes to Second-Generation Ru–Iodide Complexes: (a) HII-I2 Catalysts; (b) CAAC Catalysts Within the corresponding CAAC catalysts, we examined the Hoveyda-class complexes of C1Ph and ...

A novel metal-organic framework with one-dimensional channels {[Cd(3)(CH3COO)2(H2O)2] (CH3CN)x(CH3OH)y} (5), based on conformationally restricted linear 4,4′-bis(1-imidazolyl)biphenyl (3) and cadmium ...

Ligand Pharmaceuticals, Inc. is a biopharmaceutical company, which engages in the development and acquisition of technologies that help pharmaceutical companies to discover and develop medicines ...

The prediction of precise protein-ligand binding activities can accelerate drug discovery by virtual screening-a computational technique that predicts whether a small molecule ligand is able to bind ...

ASCO 2025 Phase 3 AMPLITUDE trial, Niraparib and abiraterone acetate plus prednisone, metastatic castration-sensitive prostate cancer, alterations in homologous recombination repair genes.