Seven-transmembrane receptors (7TMRs), also known as G protein-couple receptors, are the largest class of transmembrane receptors and a common target for therapeutics. Initially thought to signal ...
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Division of Medicinal Chemistry, Amsterdam Institute of Molecular and Life Sciences, Faculty of Science, Vrije Universiteit Amsterdam, De Boelelaan 1108, 1081 HZ Amsterdam, The Netherlands ...
In a surprising discovery, scientists have found that the heart possesses "sweet taste" receptors, similar to those on our tongues, and that stimulating these receptors with sweet substances can ...
That greater success stems in part from the fact that by engaging the same receptors stimulated by fentanyl and other illicit opioids, buprenorphine (and methadone) can greatly blunt cravings and ...
Xenoturbella bocki is a small marine worm predominantly found on the seafloor of fjords along the west coast of Sweden. This simple organism’s unusual evolutionary history has long intrigued ...
Recent studies have shown that astrocytes are GABAceptive and GABAergic astrocytes express GABA A receptors, GABA B receptors, and GABA transporter proteins to capture and internalize GABA.
Frizzleds (Fzd) are the primary receptors for Wnt morphogens, which are essential regulators of stem cell biology, yet the structural basis of Wnt signaling through Fzd remains poorly understood. Here ...
Figure 1. Signal transduction mechanism of EGFR (epidermal growth factor receptor) transactivation by angiotensin II (AngII) in vascular smooth muscle cells leading to vascular remodeling. Please note ...
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