While it is widely accepted as the primary binding site for Wnt ligands, alternative models suggest that co-receptors, such as LRP5/6, or the lipid bilayer environment, may modulate this interaction.

Get Instant Summarized Text (Gist) Both activation (agonism) and blockade (antagonism) of the GIP receptor reduce body weight and food intake, but through distinct brain mechanisms. GIPR agonists ...

Now, researchers have taken a decisive step towards understanding how. “This single receptor is responsible for our insatiable, never-ending attraction to sugar,” says Columbia neuroscientist ...

The receptors are encoded by two genes (THRA and THRB), each of which undergoes alternate splicing to generate receptor subtypes (TRα1, TRβ1, and TRβ2), with differing tissue distributions ...

Citation: Discovery of dopamine receptors in overlooked brain region sheds light on complex circuitry for anxiety and depression (2025, May 7) retrieved 25 May 2025 from https://medicalxpress.com ...

Researchers have discovered distinct roles for two dopamine receptors located on nerve cells within the portion of the brain that controls approach vs. avoidance behavior. Mount Sinai researchers ...

We assessed baseline clinical tumor size (cT) and clinical nodal status (cN) as prognostic factors using stratified (by trial and treatment) Cox models separately for hormone receptor–positive versus ...

Find more information on the Altmetric Attention Score and how the score is calculated. G protein-coupled receptors (GPCRs) transduce information encoded by external stimuli into an appropriate cell ...