Atherosclerotic arteries aren’t just a problem for the heart—they’re bad news for the brain, too. Now, scientists led by Wei Wang, Dai-Shi Tian, and Chuan Qin of Huazhong University of Science and ...

What goes wrong first in the Alzheimer’s disease brain? Scientists led by Marc Aurel Busche of the U.K. Dementia Research Institute at University College London may have an answer. In the May 7 Neuron ...

Stefan Mueller Institute of Biochemistry II, Goethe University Frankfurt Contact Information Stefan Mueller Frankfurt, Germany Professional Information Professor Institute of Biochemistry II, Goethe ...

Financial Disclosure Member reports the following financial or other potential conflicts of interest: [Last updated: May 20, 2025] Employee of AC Immune SA ...

In a milestone for Alzheimer’s disease diagnosis and care, the U.S. Food and Drug Administration on May 16 cleared for marketing the first AD blood test. Fujirebio’s Lumipulse G p-tau217/Aβ42 ...

Neurofibrillary tangles mark Alzheimer’s disease and a plethora of primary tauopathies. How best to study them in the lab? Most mouse tauopathy models overexpress the human tau protein and are highly ...

As biomarker testing becomes more common in Alzheimer’s research, scientists face the tricky question of whether to disclose results. In studies of hypothetical scenarios, including a recent survey ...

Yanling Wang Rush University Contact Information Yanling Wang Chicago Professional Information Associate Professor Rush University ...

Creating models for primary tauopathies sounds simple enough. Select a human tau gene variant that causes disease, stick it where the endogenous mouse gene sits in its genome, then wait a few months ...

The MCI-Park mice are compound mutant (Ndufs2fl/fl; DAT IREScre/+) animals in which Ndufs2, a gene encoding a core subunit of the mitochondrial respiratory chain, is selectively inactivated in ...

Now that doctors are prescribing anti-amyloid therapies for Alzheimer’s disease, scientists have begun to focus their energy on the other pathological hallmark of AD, neurofibrillary tangles. While ...

From April 24-25, the Tau Global Conference, a.k.a. Tau2025, drew 600 people to a hotel in Hyde Park, London, with 500 more following the science online. Attendance well surpassed Tau2020, the first, ...