We analysed clinical trials of pharmacological interventions on patients with amyotrophic lateral sclerosis (ALS), and compared study quality and design features. The systematic review included ...

Department of Clinical Neurosciences, University of Cambridge Clinical School, Addenbrooke’s Hospital, Cambridge CB2 0QQ, UK N Robertson, Helen Durham Neuro-inflammatory Centre, Department of ...

Department of Diagnostic Radiology, University of Bern, Switzerland. Neurological signs and computed tomographic morphology were compared in 60 patients. The primary neurological deficit was most ...

Atypical facial pain is an unrecognised and unhelpful diagnosis but one which describes chronic pains that do not fit the present classification system. Due to the site of the pain, patients may seek ...

Background Cerebral small vessel disease (SVD) has been suggested to be more common in Asians compared with Caucasians. However, data from population-based studies in Asia are lacking. We report on ...

3 Cleveland Clinic Lou Ruvo Center for Brain Health, Las Vegas, Nevada, USA Correspondence to Dr Jeffrey Cummings, Cleveland Clinic Lou Ruvo Center for Brain Health, 888 W. Bonneville Avenue, Las ...

Background Previous natural history studies highlighted a consistent heterogeneity of disability trajectories among ...

Objective: Parkinson’s disease (PD) is a progressive neurological disorder characterised by a large number of motor and non-motor features that can impact on function to a variable degree. This review ...

Objectives: Bilateral chronic high frequency stimulation of the subthalamic nucleus (STN), through the stereotactical placement of stimulating electrodes, effectively improves the motor symptoms of ...

Correspondence to Dr Ruth Ann Marrie, Internal Medicine, University of Manitoba College of Medicine, Winnipeg, MB R3A 1R9, Canada; rmarrie{at}hsc.mb.ca Pain can be one of the worst symptoms of ...

Background Shift work, which often results in sleep deprivation and circadian desynchrony, has been associated with increased risk of multiple sclerosis (MS). We aimed at studying the impact of sleep ...