Proteins and lipids to be transported are sorted to specific sites on the donor membrane, or compartment, and transport vesicles bud with the aid of cytosolic complexes of coat proteins.

More information: Xiuming Liang et al, Engineering of extracellular vesicles for efficient intracellular delivery of multimodal therapeutics including genome editors, Nature Communications (2025 ...

Genetic studies in yeast suggest that atox1 plays a role in copper delivery to the secretory pathway. Because Atox1 interacts with the Wilson ATPase in a copper-dependent fashion, impairment of ...

Cellular communication is a critical process that relies on exocytosis, during which cells release stored chemical messengers contained within intracellular nanoscale vesicles (50–500 nm in diameter).

2003). According to this view the secretory route would include insertion of proteins in the PV membrane, which then would move along the membrane network by lateral diffusion. Only at the end of ...

Extracellular vesicles (EVs) are nanosized membrane-bound structures released by cells that are able to transfer nucleic acids, protein cargos, and metabolites to specific recipient cells, allowing ...

Peer ReviewDownload a summary of the editorial decision process including editorial decision letters, reviewer comments and author responses to feedback. Microtubule-associated cargo transport, a ...

We assessed proinflammatory cytokines and activation markers for astrocytes and microglia in brain tissues from mice post-MI. Cytokine arrays (Figure [A]) showed an increase in cytokines associated ...

Female anatomy includes the internal and external structures, including those responsible for hormones, reproduction, and sexual activity. The female reproductive system is essential for hormone ...

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