Q1 2025 Earnings Conference Call May 8, 2025 8:00 AM ETCompany ParticipantsChristine Chiou - Senior Vice President, ...

The gene responsible for CF was discovered in 1989, but until the work of Vertex scientists led by Negulescu, treatments for CF addressed only its symptoms rather than the underlying cause of disease.

Somewhere between 20% and 50% of PNH patients treated with Soliris or other drugs in the C5 inhibitor class can't get symptoms under ... and idiopathic membranous nephropathy (IMN).

The median survival after diagnosis is 10 years, although some patients can survive for decades with only minor symptoms ... and Idiopathic membranous nephropathy (phase 2).

Therapy should include either belimumab or a calcineurin inhibitor, plus one or more conventional medications such as ...

Renal biopsy remains the gold standard for diagnosis, with the pathognomonic finding of predominant or codominant mesangial IgA deposits on immunofluorescence.

Immunological tests can differentiate proliferative from non-proliferative lupus nephritis, but anti-C1q antibodies and urinary erythrocytes have the best predictive power to dist ...