However, many mammalian transcription factors function differently at divergent complex eukaryotic promoters, in some cases acting as either an activator or repressor, depending on the context.

This valuable study focuses on defining how the HSP70 chaperone system utilizes J-domain proteins to regulate the heat shock response-associated transcription factor HSF1. Using a combination of ...

The course focuses on current understanding of the structure and function of eukaryotic transcription factors. The aim of the first general part is to give the student an understanding of the main ...

Several genetic studies have attempted to explore the fungal factors involved in antiviral responses, but the exact genes and ...

In a new study published in Cell Reports, researchers at the University of Freiburg reveal how a disordered protein segment ...

When the workload on the heart increases, the ventricular wall may thicken too, known as cardiac hypertrophy. This is an adaptive response that reduces pressure on the heart and maintains the activity ...

Several genetic studies have attempted to explore the fungal factors involved in antiviral ... defense involving RNA editing, RNAi, and transcription start site switching, closely linked to ...

The yeast nuclear endonuclease Rnt1 has a well-characterized role in the maturation of many ncRNA precursors. However, the scope and consequence of its function in mRNA degradation pathways is much ...

Reshma Bano is a postdoctoral research fellow at the Department of Physics, University of Surrey. She earned her PhD in ...

Transcriptional activation of the interferon‐β (IFN‐β) gene requires assembly of an enhanceosome containing the transcription factors ATF‐2/c‐Jun, IRF‐3/IRF‐7, NF‐κB and HMGI(Y). These factors ...

A study published in the journal Cell marks the first reported instance of generative AI designing synthetic molecules that can successfully control gene expression in healthy mammalian cells.