However, many mammalian transcription factors function differently at divergent complex eukaryotic promoters, in some cases acting as either an activator or repressor, depending on the context.

The course focuses on current understanding of the structure and function of eukaryotic transcription factors. The aim of the first general part is to give the student an understanding of the main ...

Several genetic studies have attempted to explore the fungal factors involved in antiviral responses, but the exact genes and ...

When the workload on the heart increases, the ventricular wall may thicken too, known as cardiac hypertrophy. This is an adaptive response that reduces pressure on the heart and maintains the activity ...

The yeast nuclear endonuclease Rnt1 has a well-characterized role in the maturation of many ncRNA precursors. However, the scope and consequence of its function in mRNA degradation pathways is much ...

Intracellular protein trafficking and secretion of proteins into the extracellular environment are sequential and tightly ...

Here we asked how genetic modifications shape the dose–response curve of biosensors based on metabolite-responsive transcription factors. Using the lac system in Escherichia coli as a model system, we ...

Scanning of the mRNA transcript by the preinitiation complex (PIC) requires a panel of eukaryotic initiation factors, which includes eIF1 and eIF1A, the main transducers of stringent AUG selection.