Hosted on MSN5mon
DNA-binding C2H2 zinc finger proteins also regulate RNA processing, researchers discover
C2H2 zinc finger proteins are the largest group of DNA-binding factors for transcription—the process of copying genetic information from DNA to messenger RNA (mRNA). As there are more than 700 ...
Nature5y
Monocytic leukemia zinc-finger protein MOZ and its related factor MORF are new histone acetyltransferases
The monocytic leukemia zinc-finger protein (MOZ) gene is rearranged in t(8; 16)(p11; p13) and inv(8)(p11q13) associated with acute myeloid leukemia. The other fusion partners involved are CBP and ...
The Scientist10mon
Designer zinc-fingers
Understanding of the DNA-binding characteristics of zinc-finger protein transcription factors has made it possible to design ZFPs to bind to specific target sequences and these designed ZFPs have been ...
The Scientist13y
When Zinc Fingers Miss the Mark
Zinc finger nucleases are designed to be like heat-seeking missiles, precisely targeted to find and cut specific sequences of DNA. Occasionally, however, they may snip the wrong spot, causing ...
BioWorld6d
Molecular glue degraders described in Bristol Myers Squibb patent
A Bristol Myers Squibb Co. patent detailed new substituted phenyl oxooxazolyl piperidine dione molecular glue degraders acting as DNA-binding protein Ikaros (IKZF1), zinc finger protein Helios (IKZF2) ...